Fig. 7: PRS selection using coefficient of variation workflow. | Nature Communications

Fig. 7: PRS selection using coefficient of variation workflow.

From: A multi-ethnic polygenic risk score is associated with hypertension prevalence and progression throughout adulthood

Fig. 7: PRS selection using coefficient of variation workflow.

Flowchart describing the selection of PRS according to the coefficient of variation (CV) criterion. The data set is split into five independent sub-datasets (without related individuals between the subsets). An association model is fit on each sub-dataset for each PRS. Each PRS, defined by a unique combination of tuning parameter, has 5 independent effect size estimates. We compute the CV for each such PRS, and select the PRS that minimizes the CV.

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