Fig. 1: SARS-CoV-2 alters the lipid composition of its host cells.
From: A global lipid map reveals host dependency factors conserved across SARS-CoV-2 variants
A Lipidomics study design. B Principal component analysis of 293T-ACE2 cells infected with SARS-CoV-2 or mock-infected (n = 5 biological replicates; each point represents one biological replicate). C Individual lipid species characterized by abundance in SARS-CoV-2 infection relative to mock in HEK293T-ACE2 cells (data points are means from five biological replicates; each data point represents a lipid species). Only significantly changed (P < 0.05, one-way ANOVA, with Benjamini–Hochmini adjustment for multiple comparisons) lipids are shown. Log2(Fold Change) relative to mock infection is shown on the x-axis. Individual lipid species are colored by the class of lipid that they belong to. DAG diacylglycerol; TAG triacylglycerol; PC phosphatidylcholine; PE phosphatidylethanolamine; PG phosphatidylglycerol; PI phosphatidylinositol; PS phosphatidylserine; CL cardiolipin; Cer ceramide; HexCer hexosylceramide; SM sphingomyelin; Carn acylcarnitine; CE cholesterol ester. D Individual lipid species characterized by abundance in SARS-CoV-2 infection relative to mock in A549-ACE2 cells (data points are means from 5 biological replicates; each data point represents a lipid species). Only significantly changed (P < 0.05, one-way ANOVA, with Benjamini–Hochmini adjustment for multiple comparisons). Same colors and abbreviations as in (C) apply. Source data are provided in Supplementary Data 1 (HEK293T-ACE2 cells) and Supplementary Data 2 (A549-ACE2 cells).
