Fig. 8: Scheme of adipocyte-derived kynurenine promoting obesity and insulin resistance. | Nature Communications

Fig. 8: Scheme of adipocyte-derived kynurenine promoting obesity and insulin resistance.

From: Adipocyte-derived kynurenine promotes obesity and insulin resistance by activating the AhR/STAT3/IL-6 signaling

Fig. 8: Scheme of adipocyte-derived kynurenine promoting obesity and insulin resistance.The alternative text for this image may have been generated using AI.

Over nutrition induces overexpress IDO1 in adipocytes, which then produce copious amount of Kyn, thereby exacerbating insulin resistance and obesity via the AhR/STAT3/IL-6 axis, while PLP catalyze Kyn catabolism to efficiently prevent insulin resistance and obesity.

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