Fig. 7: Structure of the N2 sub-domain of IF2 in the 70S-IC.
From: Compact IF2 allows initiator tRNA accommodation into the P site and gates the ribosome to elongation
a Overview of extended IF2 in the 70S-IC with domains colored as in Fig. 1. The N2 sub-domain of IF2 (brown) interacts with the shoulder domain of the 30 S subunit. b Magnified view of the N2 sub-domain bound to the shoulder region of the 30 S subunit. The locally refined EM density map is shown as gray mesh. c, d Insets from panel b. c Interactions and surface complementarity between the N2-globular sub-domain of extended IF2 and helix h16 of 16 S rRNA. d The tail emerging from the N2 sub-domain of IF2 wraps around the minor groove of h16.
