Fig. 1: Comparison of STAT5 phosphorylation in various human T cells subsets after treatment with HSA-L2wt and HSA-IL2m. | Nature Communications

Fig. 1: Comparison of STAT5 phosphorylation in various human T cells subsets after treatment with HSA-L2wt and HSA-IL2m.

From: Selective activation and expansion of regulatory T cells using lipid encapsulated mRNA encoding a long-acting IL-2 mutein

Fig. 1

HSA-IL2wt and HSA-IL2m titrations on A memory Tregs, B memory CD4+ conventional T cells, and C memory CD8+ T cells after 30 min incubation. Kinetics of STAT5 phosphorylation with 10 nM of HSA-IL2wt and HSA-IL2m on D memory Tregs, E memory CD4+ conventional T cells, and F memory CD8+ T cells. Data are presented as mean ± s.d. EC50 are derived from log-logistic fit. Statistical analysis from two-way ANOVA with Dunnet’s multiple comparison to baseline, two-sided (p-value * < 0.05, ** < 0.01, *** < 0.001, **** < 1e−4, ns = not significant, n = 4). Source data are provided as a Source Data file.

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