Fig. 7: tSV are enriched in miRs with considerable functional equivalence to EVs miRs. | Nature Communications

Fig. 7: tSV are enriched in miRs with considerable functional equivalence to EVs miRs.

From: T-cell trans-synaptic vesicles are distinct and carry greater effector content than constitutive extracellular vesicles

Fig. 7: tSV are enriched in miRs with considerable functional equivalence to EVs miRs.

a Abundance of different genome-mapped RNA species was found associated with tSV, syngeneic EVs, and parental TH or CTL cells. b–c Venn diagram showing the overlap of enriched miR species associated with tSV, EVs, and parental cells for TH (b) and CTL (c) (see also Supplementary Data 3). d miR heterogeneity is further reflected by PCA of the analyzed tSV and EVs. e–h MEME analyses revealed consensus motifs (central inserts) mapped in miRs of TH tSV (e), TH EVs (f), CTL tSV (g), and CTL EVs (h). i Number of miR species enriched uniquely in tSV (violet), uniquely in EVs (green), or shared (gray) annotated according to their GO categories. MiR targets are summarized in Supplementary Data 4. Data from n = 8 biologically independent samples (donors, a–i) from six independent experiments. For functional and biological pathway enrichment analyses using MIENTURNET (s) P values were determined by hypergeometric statistic test and FDR (Q = 0.05).

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