Fig. 2: Trimester of vaccination affects vaccine-induced antibody titer in maternal samples. | Nature Communications

Fig. 2: Trimester of vaccination affects vaccine-induced antibody titer in maternal samples.

From: Maternal immune response and placental antibody transfer after COVID-19 vaccination across trimester and platforms

Fig. 2

A The dot plots show the Spike-directed IgG1 and FcR-binding in maternal samples by trimester of vaccination. Significance was determined by Kruskal–Wallis test. No significant differences were found. The black diamond represents the group median. B The dot plots show the Spike-directed antibody-dependent cellular phagocytosis (ADCP), antibody-dependent neutrophil phagocytosis (ADNP), antibody-dependent complement deposition (ADCD) and antibody-dependent NK cell degranulation, as measured by % CD107a + NK cells, in maternal samples by trimester of vaccination. Significance was determined by Kruskal–Wallis test. No significant differences were found. The black diamond represents the group median. C The polar plots show the mean percentile rank for Spike-specific features in the first, second, and third trimesters of vaccination. D A PLSDA was built using LASSO-selected antibody features in maternal plasma for mothers who received Ad26.COV2.S, mRNA-1273, or BNT162b2 using the trimester of vaccination as the outcome variable. Each dot represents a sample, with the color representing the trimester. The ellipses represent the 95% confidence interval for the trimester. Source data are presented in Source Data File 1.

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