Fig. 1: Manhattan plot showing genome-wide significant loci associated with pelvic organ prolapse and QQplot. | Nature Communications

Fig. 1: Manhattan plot showing genome-wide significant loci associated with pelvic organ prolapse and QQplot.

From: Advancing our understanding of genetic risk factors and potential personalized strategies for pelvic organ prolapse

Fig. 1

a Manhattan plot for GWAS meta-analysis for pelvic organ prolapse The novel candidates are highlighted as a black diamond. The y axis represents −log10(P-values) for association of variants with POP, from mixed logistic regression analysis of cohorts (adjusted by year of birth and 10 principal components). The horizontal dashed line represents the threshold for genome-wide significance (P < 5 × 10−8). b QQ plot. The panel displays a QQ plot, which show the −log10(P-values) based on a two-sided Z-tests for all SNPs. The dotted line represents the expected −log10(P-values) under the null hypothesis.

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