Fig. 2: Evidence for pelvic organ prolapse GWAS meta-analysis candidate gene mapping. | Nature Communications

Fig. 2: Evidence for pelvic organ prolapse GWAS meta-analysis candidate gene mapping.

From: Advancing our understanding of genetic risk factors and potential personalized strategies for pelvic organ prolapse

Fig. 2

Previous reported loci are highlighted in gray frames and previously unidentified loci in yellow frames. We prioritized candidate genes considering at least the presence of one of the next four main evidence levels: (1) nearest gene to the association peak (indicated by green dots); (2) genes containing shared causal variants between genetic variants and gene expression signatures unraveled by colocalization analyses (shown as orange dots); (3) genes containing coding variants or in high LD (r2 > 0.6) with these (shown as purple dots); and (4) genes which showed embryo, growth/size/body, muscle, renal/urinary system, reproductive system, digestive/alimentary system phenotypes in mutant mice.

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