Fig. 2: ATRX binding sites associate with active regulatory elements. | Nature Communications

Fig. 2: ATRX binding sites associate with active regulatory elements.

From: The chromatin remodeller ATRX facilitates diverse nuclear processes, in a stochastic manner, in both heterochromatin and euchromatin

Fig. 2

a GenoSTAN analysis in LCLs of: (left) all ATAC-seq sites of open chromatin identified in LCLs plus ATRX binding sites not in open chromatin, (right) all the ATRX binding sites identified in LCLs—active promoter (P), poised promoter (Pp), active enhancer (E), enhancer-CTCF binding site (EC), CTCF binding site (C), repressed region (R) and background (B). b Proportion of ATRX binding sites overlapping with transcription factor binding sites (TFBS). c Analysis of TFBS at ATRX binding sites (in blue) vs ATRX binding sites at TFBS (in burgundy) based on their % overlaps showing the TFBS the most enriched at ATRX binding sites. d Motif analysis of ATRX binding sites in LCLs (p-values HOMER findMotifsGenome.pl)58. e Representative image of the Myc locus highlighting the presence of ATRX enrichment at active enhancers (−525 and −428). The signals represent an average of the independent replicates (n = 3 for ATRX, H3K4me1, H3K4me3 and H3.3 ChIP-seq, n = 2 for H3K27ac ChIP-seq and n = 4 for ATAC-seq).

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