Fig. 2: Combined waffle-swimmers plot for genotypes, clinical characteristics, and duration of responses for patients treated with CX-5461. | Nature Communications

Fig. 2: Combined waffle-swimmers plot for genotypes, clinical characteristics, and duration of responses for patients treated with CX-5461.

From: Results of the phase I CCTG IND.231 trial of CX-5461 in patients with advanced solid tumors enriched for DNA-repair deficiencies

Fig. 2: Combined waffle-swimmers plot for genotypes, clinical characteristics, and duration of responses for patients treated with CX-5461.The alternative text for this image may have been generated using AI.

Left waffle panel WGS functional classification; color box; cosmic/fathmm SNV or indel; color box with diamond, SIFT-indel pathogenic; color box with square clinvar pathogenic SNV. Left-center panel clinical germline testing alleles reported as pathogenic/prob-pathogenic, VUS, WT for BRCA1/2 and PALB2. Center-right waffle panel, histotypes, prior-treatment, response evaluable; Right panel, swimmers plot of responses by dose level. Solid colour lines, time on the study (months); solid black line inset, duration of response, response end at end of the black line. n = 40 patients, source data are provided as a Source Data file.

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