Fig. 5: Homologues of AcbI and AcbS.
From: Complete biosynthetic pathway to the antidiabetic drug acarbose
a Homology searches for AcbI and AcbS; b Phylogenetic tree of AcbI and AcbS. The ones shaded in blue are predicted to be AcbS homologues (PsGTs). The ones shaded in red are AcbI homologues (GTs). The ones shaded in dark blue are AcbS whose genes do not have an AcbI partner gene within a biosynthetic gene cluster (BGC). The ones shaded in purple do not pair with another AcbI/AcbS homologue in a BGC. The ones shaded in dark purple are AcbI/AcbS homologues whose genes are part of a BGC that lacks an aminotransferase gene. The ones shaded in yellow are AcbI/AcbS homologue whose genes are part of a BGC that does not contain cyclitol biosynthetic genes.
