Fig. 1: Orientation selectivity strengthens in interneurons after eye opening.

a Two-photon imaging of viral expression of GCaMP6s under the mDlx enhancer in ferret visual cortex. The ferret images were created by the authors and published in Smith, G.B., Sederberg, A., Elyada, Y.M., Van Hooser, S.D., Kaschube, M., and Fitzpatrick, D., The development of cortical circuits for motion discrimination. Nat. Neurosci. 18, 252–261 (2015). b Three age groups, Naive (EO + 0), Brief experience (EO + 4–7), and Extended experience (EO + 8⁺). c Example cellular responses to square drifting gratings (left, black traces denote median response and gray traces denote single trials) and responsive tuning curve (right) for a Naive animal. d, e same as (c) but for a Brief and Extended experience animal respectively. f–h Cumulative distributions of orientation selectivity index (f), direction selectivity (g), and variability index (h) for Naive (blue, n = 7), Brief (magenta, n = 6), and Extended (gold, n = 5) experience animals. Shaded regions denote SEM. i Fraction of cells that are responsive (white), orientation selective (hatched), and direction selective (gray) for Naive (N, n = 7), Brief (B, n = 6), and Extended (E, n = 5) experience animals. Error bars denote SEM. Source data are provided as a Source Data file.