Fig. 1: Overall structure of the oxytocin bound OTR.
From: Structural basis for the activation and ligand recognition of the human oxytocin receptor
a Cryo-EM map of the OTR:OT:Go/q:scFv16 complex. b Molecular model of the OTR:OT:Go/q:scFv16 complex. Ligand atoms are coloured according to atom types. c Clipped surface representation of the OT orthosteric binding pocket with OT shown as bright green sticks. d Detailed interactions of OT with OTR. e Agonist potency profiles of selected mutants. Bars represent differences in IP1 accumulation potency (mean ∆pEC50 ± standard deviation from two (W188A, F291A, F292A, Q295A, L316A) or three (all other constructs) independent experiments in duplicates) compared to wtOTR. n.a., no activation. Data are provided in Supplementary Table 2 and as a Source Data file.
