Fig. 2: Ligand-induced changes in OTR activation.
From: Structural basis for the activation and ligand recognition of the human oxytocin receptor
a Superposition of active OTR:OT complex (teal) and inactive OTR:retosiban complex (orange, PDB ID: 6TPK). b Close-up on binding pockets of OT and retosiban viewed from the extracellular side. c OT and retosiban binding modes as viewed from the membrane plane. d Extracellular view of the super-positioned receptors with calculated pocket volume shown as surface representation. Arrows indicate shifts of the extracellular helix tips from inactive to active state. e Calculated pocket volumes for inactive and active OTR conformations. Pocket volumes were calculated with POVME 2.042.
