Fig. 7: Schematic representation of the substrate-binding events as part of the transport cycle. | Nature Communications

Fig. 7: Schematic representation of the substrate-binding events as part of the transport cycle.

From: Substrate binding in the mitochondrial ADP/ATP carrier is a step-wise process guiding the structural changes in the transport cycle

Fig. 7

Different stages of the transport cycle, a–d, l cytoplasmic-open state, e, k occluded state, and f–j matrix-open state. The substrates ADP and ATP have an adenine moiety (green and cyan, respectively), a ribose moiety (yellow) and two or three phosphate moieties, respectively (orange). The adenosine binding site is represented by a horseshoe shape, whereas positively charged and polar residues of the binding site are shown in blue and green, respectively. The black arrowheads show the substrate movements that induce the conversion between states, whereas the red ones indicate entry and exit of the substrates.

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