Fig. 1: Schematic of the experimental concept and setup. | Nature Communications

Fig. 1: Schematic of the experimental concept and setup.

From: Confinement anisotropy drives polar organization of two DNA molecules interacting in a nanoscale cavity

Fig. 1

a Schematic of two differentially stained equal-sized dsDNA molecules confined in elliptical compartments of varying eccentricity. b Schematic of a larger dsDNA molecule and a plasmid molecule confined in the same structures. c, d Molecular confinement is induced mechanically by using pneumatic pressure to depress a thin membrane lid. Depression of the lid traps the molecules in nanoscale cavities embedded in the floor of a nanoslit flow-cell. e Zoomed-out view of device: the cavities are defined in a nanoslit that is interfaced to the flexible membrane lid at a central window etched through a supporting silicon frame.

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