Fig. 7: Graphical abstract of WASp:RPA alliance in genome stability.
From: WASp modulates RPA function on single-stranded DNA in response to replication stress and DNA damage
Shown are the sequential steps in the HR pathway involved in DNA repair or replication reactions, and the effect of WASp deficiency on RPA-coupled mis-regulation of these critical steps/reactions, which ultimately lead to genome instability, spontaneously or insult-induced.
