Fig. 7: Putative working model of MIGA2 at the ERMCS. | Nature Communications

Fig. 7: Putative working model of MIGA2 at the ERMCS.

From: Structural basis for mitoguardin-2 mediated lipid transport at ER-mitochondrial membrane contact sites

Fig. 7: Putative working model of MIGA2 at the ERMCS.The alternative text for this image may have been generated using AI.

Based on the results of this study, we propose a putative lipid trafficking mechanism for MIGA2 between ER (blue), mitochondria (pink), and lipid droplet (yellow) membrane contact sites. MIGA2 (yellow orange) forms a complex with VAPB (gray) via the phosphorylated FFAT motif and then transfers lipids between the membranes by extracting and interiorizing lipids into its large hydrophobic cavity.

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