Fig. 2: Cross genome-methylome analysis of UV mutation signatures in cutaneous melanoma patients from BCH and TCGA cohorts. | Nature Communications

Fig. 2: Cross genome-methylome analysis of UV mutation signatures in cutaneous melanoma patients from BCH and TCGA cohorts.

From: Cutaneous and acral melanoma cross-OMICs reveals prognostic cancer drivers associated with pathobiology and ultraviolet exposure

Fig. 2

a Kaplan–Meier survival curves of melanoma patients by UV signature status in BCH (n = 50) and TCGA (n = 52). The P values were derived by log-rank test. Also shown are the DMR distributions from the crude model relative to chromosomal location (b), genomic regulatory regions (c), and CpG density regions (d) in both BCH (n = 54) and TCGA (n = 58). Enrichment analysis of hyper- and hypomethylated DMRs relative to the 450 K reference set in (c, d) was done using two-sided Chi-square test. ***p < 0.001.

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