Table 1 Met1 BC composition and clonal dynamics in vitro and in vivo.

From: Clonal barcoding with qPCR detection enables live cell functional analyses for cancer research

 

BC pool clonal dynamics in vitro

BC pool clonal dynamics in vivo

BC

Pool admix (%)

Day 7 culture (%)

Fold Change

Injection (%)

Tumor Ave (%)

ST DEV

Fold change

2

3.2300

0.7459

−4.3302

0.7459

2.6848

2.0588

3.5993

3

3.2300

0.2218

−14.5635

0.2218

0.2247

0.1327

1.0133

5

3.2300

0.1089

−29.6563

0.1089

0.0058

0.0034

−18.9076

7

3.2300

4.3510

1.3471

4.3510

1.3084

0.6790

−3.3254

8

3.2300

2.0571

−1.5702

2.0571

21.2297

4.8215

10.3204

11

3.2300

1.5696

−2.0579

1.5696

0.0050

0.0057

−311.1084

14

3.2300

0.2405

−13.4321

0.2405

0.0002

0.0002

−1250.5905

17

3.2300

0.0207

−155.6942

0.0207

0.0003

0.0007

−65.5310

18

3.2300

1.0353

−3.1198

1.0353

0.0018

0.0035

−574.2797

19

3.2300

2.8757

−1.1232

2.8757

0.1045

0.0507

−27.5278

20

3.2300

8.3150

2.5743

8.3150

0.0693

0.0357

−120.0123

21

3.2300

0.4561

−7.0825

0.4561

0.0003

0.0005

−1820.1707

22

3.2300

1.2243

−2.6383

1.2243

0.0108

0.0111

−112.9192

23

3.2300

1.7757

−1.8190

1.7757

0.0417

0.0353

−42.5619

25

3.2300

0.7883

−4.0976

0.7883

4.3674

2.2510

5.5405

26

3.2300

0.6720

−4.8067

0.6720

0.0011

0.0020

−591.8461

28

3.2300

0.3914

−8.2532

0.3914

0.0010

0.0024

−391.3256

30

3.2300

1.0937

−2.9534

1.0937

0.0070

0.0083

−156.1097

31

3.2300

1.0464

−3.0867

1.0464

0.2874

0.1328

−3.6404

33

3.2300

0.3400

−9.5010

0.3400

0.0154

0.0187

−22.1346

36

3.2300

2.7291

−1.1836

2.7291

0.0404

0.0204

−67.5049

37

3.2300

0.0587

−55.0440

0.0587

0.0019

0.0043

−30.8490

40

3.2300

0.2769

−11.6657

0.2769

0.0198

0.0075

−13.9651

42

3.2300

1.3537

−2.3860

1.3537

0.0130

0.0149

−103.7583

43

3.2300

4.1184

1.2750

4.1184

0.1688

0.0679

−24.3918

44

3.2300

0.8892

−3.6323

0.8892

0.0060

0.0073

−147.9720

45

3.2300

13.1404

4.0682

13.1404

0.0603

0.0349

−217.8255

48

3.2300

0.1662

−19.4361

0.1662

0.0067

0.0069

−24.6266

53

3.2300

25.6185

7.9314

25.6185

10.7190

2.8135

−2.3900

67

3.2300

20.5118

6.3504

20.5118

58.5972

3.7022

2.8567

73

3.2300

1.8079

−1.7866

1.8079

0.0001

0.0003

−20788.2653

  1. (Associated with data shown in Figs. 3 and 4). Clonal dynamics in vitro are represented as the fold change in BC composition of the Met1 BC Pool after 7 days in culture relative to initial admixture. Clonal dynamics in vivo are represented as the average fold change in BC composition of tumors at experimental end point relative to the Met1 BC Pool composition at the time of injection. The average contribution of each BC as a percent of total BCs in each resulting tumor (n = 10) and S.D. are indicated. Source data for average tumor composition are provided as a Source Data file.
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