Fig. 2: MT1-MMP ectopic expression in the liver induces insulin resistance.
From: Regulation of age-associated insulin resistance by MT1-MMP-mediated cleavage of insulin receptor
In all, 12-week-old male mice were injected intravenously with AAV and fed on a regular diet. a Western blotting analyses on the expression of MT1-MMP in the livers and other peripheral tissues including white adipose tissue (WAT), skeletal muscle and heart from mice receiving either AAV control, AAV-WT MT1, or AAV-MT1 EA (n = 4). b Plasma glucose level during the intraperitoneal glucose-tolerance tests (n = 6 for AAV control; n = 7 for AAV-WT MT1 & AAV-MT1 EA). c Plasma glucose level during the insulin-tolerance tests. (n = 6 for AAV control; n = 7 for AAV-WT MT1 & AAV-MT1 EA) (d–h) hyperinsulinemic/euglycemic clamp studies: plasma glucose level (d) and glucose infusion rate (GIR) during clamp studies (e), glucose disposal rate (GDR) (f), hepatic glucose production (HGP) (g), and suppression of HGP (h) in mice receiving either AAV control, AAV-WT MT1, or AAV-MT1 EA. (n = 4 for AAV control; n = 5 for AAV-WT MT1 & AAV-MT1 EA) Data are reported as average ± s.e.m.; one-way ANOVA (e–h) or two-way ANOVA (b–e). Source data are provided as a Source Data file.
