Fig. 5: Pharmacological inhibition of MT1-MMP improves insulin sensitivity in aged mice.
From: Regulation of age-associated insulin resistance by MT1-MMP-mediated cleavage of insulin receptor
Male mice at 4- and 18 months old on chow diet received treatment (twice a week) with either 3A2 antibody or control IgG for 4 weeks. a, b Western blotting (a) and qPCR analyses (c) on the expression of IR in the livers. The relative expression of IR protein level in relative to β-actin levels was quantified in (b) (n = 4). d The level of sIR was measured in the plasma (n = 5). e–g Fasting plasma glucose (n = 5). e Fasting plasma insulin (n = 5). f Glucose-tolerance test (n = 5) (g) in mice. Data are reported as average ± s.e.m.; two-sided unpaired t test (e–f) or one-way ANOVA (b–d, g). Source data are provided as a Source Data file.
