Fig. 6: Elevated level of the soluble insulin receptor in aged primates.
From: Regulation of age-associated insulin resistance by MT1-MMP-mediated cleavage of insulin receptor
a, b, d, e ELISA assay reveals that there is a significant upregulation of both plasma MMP14 and soluble insulin receptor (sIR) in the plasma of healthily aged cynomolgus macaques (a, b) and human subjects (d, e) (n = 5 for non-human primates; 21 young and 23 elderly human subjects; two-sided t test). c, f There is also a positive correlation between plasma MT1-MMP and soluble insulin receptor in the plasma from aged and young non-human primates (c) and humans (f). (non-human primates: P = 0.012, R = 0.751, n = 10; human: P < 0.001, R = 0.742, n = 44; two-sided Spearman’s correlation). Data are reported as average ± s.e.m. Source data are provided as a Source Data file.
