Table 1 Novel gene-trait associations identified by TWAS.

GWAS trait	Peak GWAS SNP	Gene	NK cell cis eSNP	TWAS Z score	TWAS P value
Ulcerative colitis	rs6060341	EIF6	rs6120889	4.019	5.85 × 10⁻⁵
	rs4949874	ACADM	rs2211080	−3.874	0.0001
	rs6971	TSPO	rs138931	−3.619	0.0003
	rs6458351	NFKBIE	rs28385699	3.568	0.0004
Rheumatoid arthritis	rs7500321	SPNS1	rs7140	4.185	2.85 × 10⁻⁵
	rs968567	SCGB1D1	rs174627^a	3.996	6.44 × 10⁻⁵
Systemic lupus erythematosus	rs12758175	RPAP2	rs7522081	4.499	6.83 × 10⁻⁶
	rs7258381	IRF3	rs12104272	−4.370	1.24 × 10⁻⁵
	rs172531	RERE	rs159963	3.867	0.0001
	rs727088	*CD226*	rs1788098	−3.77	0.0002
Primary biliary cirrhosis	rs3796621	DGKQ	rs3733349	4.874	1.09 × 10⁻⁶
	rs12462708	HKR1	rs7257354	4.569	4.90 × 10⁻⁶
	rs1876829	LINC02210	rs77459448	−4.564	5.03 × 10⁻⁶
	rs3761959	FCRL3	rs2210913	−4.551	5.34 × 10⁻⁶
	rs11172113	TSFM	rs870392^a	4.227	2.37 × 10⁻⁵
	rs6945033	ZC3HAV1	rs7800079	−4.097	4.19 × 10⁻⁵
	rs1788103	*CD226*	rs1788098	−4.026	5.66 × 10⁻⁵
	rs33873	AC010175.1	rs35596029	−3.951	7.77 × 10⁻⁵
	rs7575363	POMC	rs28445639	−3.819	0.0001
	rs1467194	*TMEM163*	rs6758396	3.727	0.0002
	rs4465620	ITGAL	rs12598978	3.712	0.0002
Crohn’s disease	rs2412973	OSM	rs201712052	5.174	2.30 × 10⁻⁷
	rs7522462	IGFN1	rs940398^a	4.174	3.00 × 10⁻⁵
	rs4409689	DOCK7	rs144467554	−3.869	0.0001
	rs1035441	ZNF829	rs1148395^a	3.871	0.0001
	rs2974298	SMIM19	rs2974348	3.809	0.0001

Loci where the data support a shared causal variant between the trait GWAS and an eQTL specific to NK cells are highlighted (bold).
^aPeak eSNP not significant in primary eQTL analysis.

Quick links

Search