Fig. 5: RSV pre-F protein combined with CAF08 protects mice from RSV infection. | Nature Communications

Fig. 5: RSV pre-F protein combined with CAF08 protects mice from RSV infection.

From: CAF08 adjuvant enables single dose protection against respiratory syncytial virus infection in murine newborns

Fig. 5: RSV pre-F protein combined with CAF08 protects mice from RSV infection.

Newborn CB6F1 mice were challenged with live RSV A2 strain after single immunization at birth with the formulations indicated. Viral load was measured in lungs and nose as described in the Methods. Adjuvantation of pre-F with CAF01 or CAF08 resulted in the greatest reduction in viral carriage in the lungs and nose. All statistical comparisons are Mann–Whitney U test comparisons to saline groups (n = 6 mice/group, shown as Box-whisker plots, center:mean, boxes:75th and 25th percentile, whiskers: minimum and maximum values Statistical comparisons to SAL group employed two-tailed Mann–Whitney U test (*p < 0.05, **p < 0.01, ***P < 0.001). Source data are provided as a Source Data file.

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