Fig. 6: Changes in ERE expression during mTEC maturation.
From: Transcriptomic diversity in human medullary thymic epithelial cells
A Expression (in z-scored TPM counts) for 613 ERE subfamilies identified with SalmonTE108 in mTECs, embryonic stem cells (ESCs), and 25 GTEx tissues. B Differential expression (Wald test) of 818 ERE subfamilies detected by TEtranscripts106 during mTEC maturation, colored by class. C Overlap of expression status between genes and EREs with a TSS within the gene body ±1000 bp. The gene expression status is color-coded by the differential expression between mTEChi and mTEClo: Up upregulated, Down downregulated, UC unchanged; corresponding categorization for ERE expression on x-axis. D Contribution of ERE expression to the expression of an annotated gene for each ERE-initiated chimeric transcript unique to the mTEChi population detected by LIONS70. Transcripts are colored by gene biotype; lncRNA long non-coding RNA. Genes with annotated gene names are highlighted. E MTEChi-specific initiation event from the MER41B promoter (LTR) into the protein-coding gene LRRC61. Expression tracks show counts per million in the mTEC populations. All panels: n = 5 paired mTEC samples, n = 6 samples per GTEx tissue. Source data for A–D are provided in the Source Data file.
