Fig. 3: Cytotoxic CD4+ and CD8+ T cells are clonally expanded in NSCLC. | Nature Communications

Fig. 3: Cytotoxic CD4+ and CD8+ T cells are clonally expanded in NSCLC.

From: Integration of tumor extrinsic and intrinsic features associates with immunotherapy response in non-small cell lung cancer

Fig. 3: Cytotoxic CD4+ and CD8+ T cells are clonally expanded in NSCLC.

a UMAP projection showing the clone size associated with the TCR for each cell in CD8+ and c CD4+ T cells. b, d TCR clonal association between phenotypic states visualized using a graph structure. Each node represents a Leiden cluster and the width of each directed edge represents the percent of clones from the starting node shared with the target node. The color of each edge matches that of the starting node. Edges with weights in the lowest tertile for CD4+ and lowest quartile for CD8+ T cells are not shown for clarity. Source data are provided as a Source Data file.

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