Fig. 5: Cytotoxic gene signature is associated with ICB response in NSCLC. | Nature Communications

Fig. 5: Cytotoxic gene signature is associated with ICB response in NSCLC.

From: Integration of tumor extrinsic and intrinsic features associates with immunotherapy response in non-small cell lung cancer

Fig. 5: Cytotoxic gene signature is associated with ICB response in NSCLC.

a Kaplan–Meier plots showing time to progression stratified by cytotoxic score (CS) status in the Tempus NSCLC ICB cohort (n = 123, HR = 0.56, p = 0.029, log rank), and b the TCGA-LUAD NSCLC cohort (n = 486, HR = 1.00, p = 1.0, log rank). c Correlation of TMB and CS in the NSCLC ICB cohort (n = 123, R = −0.0098, unadjusted p = 0.91, Pearson correlation test). d Kaplan–Meier plot showing time to progression on ICB therapy, stratified by multimodal score (MM) status in the Tempus NSCLC ICB cohort (n = 123, HR = 1.94, p = 0.005, log rank) and e the HLA-I-deficient subgroup (n = 26, HR = 3.59, p = 0.017, log rank). Source data are provided as a Source Data file.

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