Fig. 5: Schematic diagram of the polymorphism of α-syn fibrils induced by heparin.
From: Heparin induces α-synuclein to form new fibril polymorphs with attenuated neuropathology
a Charge interactions of heparin with lysine residues that are buried inside the polymorphs 2a/2b fold block α-syn folds into polymorphs 2a/2b. Instead, α-syn forms a distinctive fold in complex with heparin. b Heparin disrupts the charge interactions between the protofilaments, which results in polymorphs either containing a single protofilament, or forming an interface mediated by heparin.
