Table 1 Clinically relevant measurements of vitals and mechanical ventilator settings during establishment of LPS-induced ARDS for all pigs.

From: Reduction of primary graft dysfunction using cytokine adsorption during organ preservation and after lung transplantation

 

Baseline (n = 16)

Confirmed ARDS (n = 16)

p value

Sat (%)

98.9 ± 1.4

96.1 ± 3.4

>0.9999

HR (bpm)

73.8 ± 18.2

131.8 ± 18.3

0.5670

SBP (mmHg)

101.5 ± 10.2

100.6 ± 23.4

>0.9999

DBP (mmHg)

70.6 ± 10.7

62.9 ± 24.2

>0.9999

MAP (mmHg)

83.2 ± 11.0

72.6 ± 22.6

>0.9999

CVP (mmHg)

6.8 ± 2.9

6.6 ± 2.5

>0.9999

Temp (°C)

38.5 ± 1.7

39.0 ± 2.0

>0.9999

SPP (mmHg)

25.3 ± 4.8

39.6 ± 9.4

>0.9999

DPP (mmHg)

13.5 ± 4.7

26.8 ± 8.4

>0.9999

MPP (mmHg)

18.9 ± 4.1

31.6 ± 6.8

>0.9999

Wedge (mmHg)

10.6 ± 3.4

10.4 ± 5.5

>0.9999

CO (L/min)

4.0 ± 0.9

5.8 ± 2.2

>0.9999

SVR (DS/cm5)

1517.2 ± 312.1

1044.3 ± 405.4

<0.0001

PVR (DS/cm5)

173.2 ± 68.1

364.0 ± 183.4

<0.0001

CI

2.8 ± 0.5

4.3 ± 1.6

>0.9999

pH

7.4 ± 0.1

7.3 ± 0.1

>0.9999

PaCO2 (mmHg)

40.7 ± 6.1

54.0 ± 6.2

>0.9999

PaO2 (mmHg)

247.3 ± 33.6

107.8 ± 24.5

<0.0001

Hb (g/L)

91.2 ± 10.4

95.1 ± 13.1

>0.9999

Lactate (mmol/L)

1.6 ± 0.5

2.4 ± 1.0

>0.9999

BE (mmol/L)

4.5 ± 2.7

2.1 ± 1.5

>0.9999

MV (L/min)

7.9 ± 1.1

8.5 ± 1.6

>0.9999

Max. Pressure (cmH2O)

16.7 ± 2.6

20.4 ± 3.7

>0.9999

PEEP (cmH2O)

5.0 ± 0.0

5.0 ± 0.0

>0.9999

Vt (mL)

363.9 ± 63.0

363.4 ± 52.9

>0.9999

Cdyn (mL/cmH2O)

33.1 ± 11.6

23.8 ± 4.9

>0.9999

RR (breaths/min)

21.4 ± 3.4

23.6 ± 3.4

>0.9999

PaO2/FiO2 (mmHg)

494.2 ± 53.4

213.6 ± 43.0

<0.0001

  1. Sat oxygen saturation, HR heart rate, SBP systolic blood pressure, DBP diastolic blood pressure, MAP mean arterial pressure, CVP central venous pressure, Temp temperature. Hemodynamic variables: SPP systolic pulmonary pressure, DPP diastolic pulmonary pressure, MPP mean pulmonary pressure, Wedge pulmonary artery wedge pressure, CO cardiac output, SVR systemic vascular resistance. Blood gas parameters: pH, PaO2 partial pressure of oxygen, PaCO2 partial pressure of carbon dioxide, Hb hemoglobin, lactate, BE base excess, PaO2/FiO2 partial pressure of oxygen divided by fraction of inspired oxygen. Mechanical ventilator settings with volume-controlled ventilation: MV minute volume, PIP peak inspiratory pressure, PEEP peak inspiratory pressure, positive end-expiratory pressure, Vt tidal volume, Cdyn dynamic compliance, RR respiratory rate, FiO2 fraction of inspired oxygen.
  2. Two-sided Mann–Whitney test was used for statistical analysis. P values less than 0.05 are highlighted in bold text.
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