Fig. 1: Overview of ARCHIE and Analysis pipeline.
From: Aggregative trans-eQTL analysis detects trait-specific target gene sets in whole blood
A An illustrative example for ARCHIE. Association statistics (−log10 p value) from trans-eQTL mapping for P variants and G genes are shown in the left panel heatmap. Using LD and co-expression estimated from reference datasets, ARCHIE aggregates multiple weaker trans-eQTL associations to select a subset of variants and genes which capture trait specific trans-association patterns (right panel heatmap). B Description of analysis pipeline for summary statistics of trans-eQTL mapping provided by the eQTLGen consortium by integrating external estimates from GTEx (v8) and UK Biobank. See Results and Methods for more details.
