Fig. 2: Simulation model and results.
From: Aggregative trans-eQTL analysis detects trait-specific target gene sets in whole blood
A causal network model for global null scenario with no association between the SNPs 1-40 and the Genes 1-9 (marked in blue). See Results and Methods: Simulation Model for more details. B Sparse causal network: causal regulatory network of downstream Genes 1–9 (in blue) regulated by SNPs 1-40 mediated via 8 local (cis) genes (marked in red). C Dense causal network: causal regulatory network of downstream Genes 1–9 (in blue) regulated by SNPs 1–40 mediated via 8 local (cis) genes (marked in red). For both B, C the heritability of cis gene expressions explained was maintained at 20–22% and the heritability of downstream genes (1–9) explained was maintained at 10–14%. D Empirical power to identify different gene sets within sparse causal regulatory network (B) using ARCHIE compared to standard trans-eQTL mapping. E Empirical power to identify different gene sets within dense causal regulatory network (C) using ARCHIE compared to standard trans-eQTL mapping.
