Fig. 3: Trans-association pattern and properties of selected target gene-set for Schizophrenia (SCZ).
From: Aggregative trans-eQTL analysis detects trait-specific target gene sets in whole blood
A Top 10 sparse canonical correlation values (cc-values; red) and the corresponding competitive null distributions (black box plot) for ARCHIE analysis of SCZ. Top 1 ARCHIE component is significant. The box plot for competitive null distribution is presented as ±1.5 interquartile range with the median line denoted at the center. The competitive null distribution denotes the general pattern of sparse canonical correlation (and trans-associations) expected in analysis of variants that are not specific to SCZ. The significant ARCHIE components are marked by a blue asterisk. B −-log10 (p values) for standard trans-eQTL association test between variants and genes selected in ARCHIE component 1 as reported in eQTLGen (two sided test). Any association p value < 10−08 is collapsed to 10−08 for the ease of viewing. C Pathway enrichment results for some selected top pathways for the target genes selected in gene-component 1. For full pathway enrichment results for the target genes selected see Supplementary Data 3, 4. The dashed vertical line corresponds to a suggested FDR threshold of 0.001. D trans-heritability enrichment analysis for target genes selected for SCZ. The violin plots represent the distribution of pseudo-r2 for the selected SNPs and a random gene-set of the same size on SCZ (left) and the distribution of pseudo-r2 of the selected genes and SNPs on a random trait in UK Biobank (right). The red dashed line represents the observed pseudo-r2 for the selected SNPs and target genes for SCZ (See Results and Methods for details).
