Fig. 4: Analysis of selected target gene-set for Ulcerative Colitis (UC).

A Top 10 cc-values (red) and the corresponding competitive null distributions (black box plot) for ARCHIE analysis of UC. Top 2 ARCHIE components are significant. The box plot for competitive null distribution is presented as ±1.5 interquartile range with the median line denoted at the center. The competitive null distribution denotes the general pattern of sparse canonical correlation (and trans-associations) expected in analysis of variants that are not specific to UC. The significant ARCHIE components are marked by a blue asterisk. B Pathway enrichment results (one sided test) for some selected top pathways for the selected target genes. The dashed vertical line corresponds to a suggested FDR threshold of 0.001. For full pathway enrichment results for the target genes selected for both the components see Supplementary Data 5–7. C PPI enrichment (one sided test) for the two significant ARCHIE components for UC. D trans-heritability enrichment analysis for target genes selected for UC. The violin plots represent the distribution of pseudo-r² for the selected SNPs and a random gene-set of the same size on UC (left) and the distribution of pseudo-r² of the selected genes and SNPs on a random trait in UK Biobank (right). The red dashed line represents the observed pseudo-r² for the selected SNPs and target genes for UC (See Results and Methods for details).