Table 3 Pathway enrichment results for the target genes selected for SCZ.
From: Aggregative trans-eQTL analysis detects trait-specific target gene sets in whole blood
Category | Pathway | Adjusted p value | Genes in pathway | Genes overlap | Novel genes overlap |
|---|---|---|---|---|---|
GO | Endosome (GO: 0005768) | 3.8 × 10–05 | 885 | 13 | 11 |
Vacuole (GO: 0005773) | 2.7 × 10–04 | 760 | 11 | 9 | |
Response to endoplasmic reticulum stress (GO: 0034976) | 1.3 × 10−02 | 272 | 7 | 6 | |
Hallmark | Glycolysis | 3.3 × 10−03 | 200 | 5 | 4 |
Hypoxia | 1.4 × 10−02 | 200 | 4 | 3 | |
MTORC1 signaling | 1.4 × 10−02 | 200 | 4 | 3 | |
Curated Gene sets | Wierenga_STAT5A_TARGETS_DN | 5.9 × 10−03 | 189 | 6 | 5 |
Zhou_INFLAMMATORY_RESPONSE_LIVE_DN | 6.5 × 10−03 | 372 | 7 | 3 | |
Oncogenic Signatures | TBK1. DN.48HRS_DN | 3.1 × 10−02 | 50 | 3 | 3 |
ATF2_S_UP. V1_DN | 4.4 × 10−02 | 185 | 4 | 4 | |
Immunologic Signatures | GSE6269_E_COLI_VS_STREP_PNEUMO_INF_PBMC_DN | 3.9 × 10−07 | 166 | 9 | 8 |
GSE6269_E_COLI_VS_STAPH_AUREUS_INF_PBMC_DN | 2.1 × 10−04 | 174 | 7 | 5 |
