Table 4 Pathway enrichment results for the target genes selected for UC.
From: Aggregative trans-eQTL analysis detects trait-specific target gene sets in whole blood
Component | Category | Pathway | Adjusted p value | Genes in pathway | Genes overlap | Novel genes overlap |
|---|---|---|---|---|---|---|
1 | GO | Regulation of Immune system (GO: 0002683) | 8.5 × 10−09 | 1606 | 25 | 11 |
Lymphocyte activation (GO: 0046649) | 8.5 × 10−09 | 709 | 18 | 8 | ||
Regulation of T-cell activation (GO: 0050863) | 2.9 × 10−06 | 311 | 11 | 6 | ||
Hallmark | IL2 STAT5 signaling | 3.2 × 10−10 | 200 | 10 | 5 | |
G2M checkpoint | 2.6 × 10−03 | 200 | 4 | 4 | ||
Curated | PILON_KLF1_TARGETS_DN | 2.5 × 10−05 | 854 | 11 | 4 | |
KEGG: Endocytosis | 3.2 × 10−02 | 181 | 5 | 3 | ||
Reactome: Adaptive immune system | 2.1 × 10−02 | 807 | 10 | 3 | ||
Immunologic Signatures | GSE7460_WT_VS_FOXP3_HET_ACT_WITH_TGFB_TCONV_UP | 6.9 × 10−08 | 200 | 10 | 8 | |
GSE4984_UNTREATED_VS_GALECTIN1_TREATED_DC_DN | 4.5 × 10−16 | 191 | 16 | 7 | ||
GSE22886_NAIVE_CD4_TCELL_VS_MONOCYTE_UP | 3.2 × 10−07 | 196 | 11 | 6 | ||
2 | GO | Defense Response (GO: 0006952) | 2.0 × 10−04 | 1684 | 11 | 4 |
Inflammatory Response (GO: 0022610) | 1.2 × 10−03 | 714 | 7 | 2 | ||
Curated | JAATINEN_HEMATOPOIETIC_STEM_CELL_DN | 4.7 × 10−04 | 233 | 6 | 3 | |
Immunologic Signatures | GSE22886_NAIVE_BCELL_VS_MONOCYTE_UP | 2.1 × 10−12 | 195 | 11 | 4 | |
GSE10325_CD4_TCELL_VS_BCELL_DN | 5.8 × 10−08 | 193 | 8 | 3 |
