Fig. 6: PRV111 increased the number of TILs. | Nature Communications

Fig. 6: PRV111 increased the number of TILs.

From: A nanoengineered topical transmucosal cisplatin delivery system induces anti-tumor response in animal models and patients with oral cancer

Fig. 6: PRV111 increased the number of TILs.The alternative text for this image may have been generated using AI.

A Fold change increase in TILs after treatment of 8 patients with PRV111 relative to pretreatment biopsies, shown as average ± SEM (p < 0.001; Student’s unpaired t-test). Four slides were analyzed for each specimen and average was used for fold change calculation. B Representative images (10×; scale bar—1000μm) of pre- and post-treatment sections stained for CD3, CD8, and CD4 T cells. Changes in brown staining indicates increase in tumor-infiltrating lymphocytes following PRV111 treatment. Source data are provided as a Source Data file.

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