Fig. 2: Measures of purifying selection in protein-coding genes by biological pathway.
From: Extreme purifying selection against point mutations in the human genome
Genes were assigned coarse-grained functional categories using the top-level annotation from the Reactome pathway database31. An estimates for each category is shown for both ExtRaINSIGHT (λs; teal) and INSIGHT (ρ; orange). Error bars are centered at the MLE and indicate one standard error in each direction (see “Methods”). Total number of genes: n = 19,256 (ranging from 125 to 2707 per category).
