Table 2 Weaker selection across the human genome (based on INSIGHT).

Feature	ρ	± (stderr)	no. sites (M)	prop. sites	exp. no. (M)^a	exp. prop.^b	fold enrich.	exp. del.^c
CDS	0.624	0.020	33.8	1.18%	19.7	21.5%	18.2	0.47
5\(^{\prime}\) UTR	0.222	0.035	8.2	0.29%	1.5	1.6%	5.6	0.04
3\(^{\prime}\) UTR	0.237	0.033	36.1	1.26%	7.0	7.7%	6.1	0.17
splice	0.883	0.013	0.8	0.03%	0.7	0.7%	26.3	0.02
nonconserved lncRNA^d	0.025	0.020	453.6	15.78%	0.0	0.0%	0.0	0.00
conserved lncRNA^e	0.412	0.019	23.3	0.81%	8.6	9.4%	11.6	0.21
nonconserved intron^d	0.042	0.022	972.6	33.83%	0.0	0.0%	0.0	0.00
conserved intron^e	0.426	0.019	44.3	1.54%	17.0	18.5%	12.0	0.41
nonconserved intergenic^d	0.059	0.036	1255.5	43.67%	21.7	23.6%	0.5	0.52
conserved intergenic^e	0.376	0.020	46.9	1.63%	15.7	17.0%	10.4	0.38
Total			2875.1	100.00%	91.9	100.0%		2.21

^aExpected number of deleterious sites after adjusting for background. In this case, the estimate for nonconserved introns (0.022) was subtracted from each estimate of ρ.
^bExpected proportion of deleterious sites after adjusting for background.
^cExpected number of new deleterious mutations per diploid individual, assuming a mutation rate of 1.2 × 10⁻⁸ per generation per site.
^dSites not classified as conserved by phastCons.
^eSites classified as conserved by phastCons.

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