Fig. 2: Camk4 deficiency alleviates the severity of IMQ-induced psoriasis. | Nature Communications

Fig. 2: Camk4 deficiency alleviates the severity of IMQ-induced psoriasis.

From: Calcium/calmodulin-dependent protein kinase IV promotes imiquimod-induced psoriatic inflammation via macrophages and keratinocytes in mice

Fig. 2: Camk4 deficiency alleviates the severity of IMQ-induced psoriasis.The alternative text for this image may have been generated using AI.

a Representative photos of mouse back skin. b Scoring curves of back skin thickness, scaling, and erythema. c H&E staining of skin sections. Scale bar = 200 μm. d Statistical analysis of epidermal thickness. a–d N = 7–8 per group from two independent experiments. e RNA sequencing analysis of the whole skin showing differentially expressed genes associated with cytokines, chemokines, AMPs, epidermis development, tissue repair, and phagocytosis between IMQ-treated Camk4+/+ and Camk4−/− mice (n = 3 biologically independent samples). f The expression of pathogenic factors in the skin of IMQ-treated mice as determined by quantitative PCR (n = 4 biologically independent samples). Data are shown as mean ± SD. For (b, d, e), two-sided unpaired Student’s t test; for (f), two-sided Mann–Whitney test and two-sided unpaired Student’s t test. Source data are provided as a Source Data file.

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