Fig. 9: CaMK4 inhibitor ameliorates IMQ-induced psoriasis. | Nature Communications

Fig. 9: CaMK4 inhibitor ameliorates IMQ-induced psoriasis.

From: Calcium/calmodulin-dependent protein kinase IV promotes imiquimod-induced psoriatic inflammation via macrophages and keratinocytes in mice

Fig. 9: CaMK4 inhibitor ameliorates IMQ-induced psoriasis.The alternative text for this image may have been generated using AI.

a Schematic representation of the mouse model. WT mice were topically treated with 62.5 mg IMQ on shaved back skin daily for 5 consecutive days. KN-93 (0.24 mg per mouse) or PBS was intravenously injected into the mice 1 h before IMQ treatment on day 0 and day 2. Samples were harvested on day 5 for subsequent experiments. b Representative photos of mouse back skin. c Scoring curves of back skin thickness, scaling, and erythema. d H&E staining of skin sections. Scale bar = 200 μm. e Statistical analysis of epidermal thickness. a–e N = 5–7 per group from two independent experiments. f The expression of pathogenic factors in the skin of IMQ-treated mice as determined by quantitative PCR (n = 3 biologically independent samples). Data are shown as mean ± SD. For (c), two-sided unpaired Student’s t test; for (e), two-sided Mann–Whitney test; for (f), two-sided Mann–Whitney test and two-sided unpaired Student’s t test. Source data are provided as a Source Data file.

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