Fig. 3: TCS induces genes related to NASH and HCC in liver.
From: Lactational delivery of Triclosan promotes non-alcoholic fatty liver disease in newborn mice
WT mice breastfed with TCS or vehicle for 21 days. a Heatmaps showing differential expression of genes related to lipogenesis, retinol metabolism and MCM and HCC in 21-day old mice (n = 3 per group). b Expression of genes associated with inflammation, fibrotic and oxidative stress (n = 3 per group). c Representative IB analysis of NQO1, SCD1 and IL-1β at 21 days (n = 1 per group). d Histological slides were stained with Sirius Red and F4/80 antibody in liver sections from TCS breastfed (21-day old) or vehicle breastfed WT mice, n = 15 images per group from 4 mice in each group. Sirius Red scale bars=50 μm and F4/80 scale bars = 20 μm (b) and (d) show mean ± S.E., determined by two-tailed Student’s test; *P < 0.05, **P < 0.01, ***P < 0.001. All genes used are significant and p adjusted value below the cut-off level of 0.05.
