Fig. 4: TCS blocks Fgf21 expression and AMPK signaling.
From: Lactational delivery of Triclosan promotes non-alcoholic fatty liver disease in newborn mice
WT mice breastfed with TCS or vehicle for 21 days. a Hepatic expression of Fgf21 was measured by Q-RT-PCR, vehicle WT, n = 7; vehicle Pparα−/−, n = 3; TCS WT, n = 8; TCS Pparα−/−, n = 3. and FGF21 serum levels were evaluated by ELISA in 21-day old mice, n = 4 per group. b IB analysis of total and phosphorylated AMPK and expression of AMPK target genes from TCS and WT mice in liver of 21-day old neonatal mice (n = 3 per group). (a) and (b) show mean ± S.E., determined by two-tailed Student’s test; *P < 0.05, **P < 0.01. AMPK target genes used are significant and p adjusted value below the cut-off level of 0.05.
