Fig. 6: PPARα controls DNL in liver of mice exposed to lactational TCS. | Nature Communications

Fig. 6: PPARα controls DNL in liver of mice exposed to lactational TCS.

From: Lactational delivery of Triclosan promotes non-alcoholic fatty liver disease in newborn mice

Fig. 6: PPARα controls DNL in liver of mice exposed to lactational TCS.The alternative text for this image may have been generated using AI.

WT and Pparα−/− neonatal mice breastfed with vehicle or TCS for 21 days. a Expression of PPARα target genes at 21 days, n = 6 mice per group. b Expression of genes linked to hepatic lipogenesis, WT, n = 6 per group and Pparα−/−, n = 4 per group. c Hepatic IB analysis of FASN and SCD1 (n = 2 mice per group). d Measurement of liver triglycerides (TG) at 21 days, n = 4 mice per group. e Frozen liver sections were stained with ORO (n = 3 per group). Scale bar, 20μm. (a, b and d) show mean ± S.E., determined by two-tailed Student’s test; *P < 0.05, **P < 0.01, ***P < 0.001.

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