Fig. 7: Orally administration of OCA suppresses DNL genes, PPARα activity and ER stress in liver of TCS breastfed mice. | Nature Communications

Fig. 7: Orally administration of OCA suppresses DNL genes, PPARα activity and ER stress in liver of TCS breastfed mice.

From: Lactational delivery of Triclosan promotes non-alcoholic fatty liver disease in newborn mice

Fig. 7: Orally administration of OCA suppresses DNL genes, PPARα activity and ER stress in liver of TCS breastfed mice.The alternative text for this image may have been generated using AI.

Neonatal mice receiving a normal diet or TCS through lactation for 21 days. During the course of this exposure, 16-day old mice were treated with OCA for 4 days and tissues collected on day 21. a Expression of hepatic Shp (vehicle, n = 3 per group and TCS, n = 4 per group). b Expression of genes associated with lipogenesis (vehicle, n = 3 per group and TCS, n = 4 per group). c Hepatic expression of PPARα target genes (vehicle, n = 3 per group and TCS, n = 4 per group). d Hepatic expression of Fgf21 (vehicle veh, TCS veh and TCS OCA, n = 4 per group and vehicle OCA, n = 3). e Measurement of liver TG (n = 4 per group). f Genes linked to ER stress (vehicle veh and TCS veh, n = 5 per group, TCS OCA, n = 4 and vehicle OCA, n = 3). g Hepatic IB analysis of ATF4 and FASN (n = 2 per group). h Frozen liver sections were stained with ORO (n = 3 per group). Scale bar, 20μm. (a–f) show mean ± S.E., determined by two-tailed Student’s test; *P < 0.05, **P < 0.01, ***P < 0.001.

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