Table 3 Klebsiella genotype association with infection

From: Combined comparative genomics and clinical modeling reveals plasmid-encoded genes are independently associated with Klebsiella infection

Genotype

Case frequency

Control frequency

Unadjusted

Adjusted for clinical variables

Odds ratio

P-value

Odds ratio

P-value

Virulence determinants

Ā Ā Ā Ā Ā Ā 

ybt

0.207

0.133

1.7

0.144

1.78

0.155

col

0.024

0.007

3.72

0.286

0.629

0.709

iuc

0.024

0.007

3.72

0.286

0.436

0.507

iro

0.012

0.007

1.84

0.668

0.476

0.602

rmpA

0.024

0.007

3.72

0.286

0.436

0.507

rmpA2

0.012

0.007

1.84

0.668

0.937

0.964

AMR determinants*

Ā Ā Ā Ā 

AGly acquired (aminoglycosides)

0.268

0.067

5.133

7.01E-05

3.77

0.00427

Flq (fluoroquinolones)

0.220

0.040

6.75

1.14E-04

6.69

0.000507

MLS (macrolides)

0.098

0.013

8.0

0.010

6.41

0.0649

Phe (phenicols)

0.171

0.027

7.51

0.001

6.35

0.00332

Rif (rifampin)

0.012

0.000

N/A

N/A

N/A

N/A

Sul (sulfonamides)

0.268

0.047

7.49

1.22E-05

5.19

0.00226

Tet (tetracyclines)

0.183

0.100

2.01

0.076

1.88

0.128

Tmt (trimethoprim)

0.244

0.053

5.73

8.86E-05

4.28

0.00285

Omp mutation

0.037

0.020

1.86

0.453

1.55

0.676

Bla (β-lactamase that is ā€œotherā€)

0.573

0.520

1.24

0.438

1.27

0.379

Bla Carb (carbapenemase)

0.061

0.007

9.68

0.040

36.2

0.00151

Bla ESBL (extended-spectrum β-lactamases)

0.207

0.087

2.76

0.011

2.94

0.0116

Bla broad (broad-spectrum β-lactamases)

0.354

0.347

1.03

0.915

0.902

0.734

Bla broad inhR (broad-spectrum β-lactamases with resistance to β-lactamase inhibitors)

0.110

0.107

1.03

0.942

1.05

0.922

  1. *Kleborate25 predicted AMR genotypes absent in our dataset are not shown.
  2. Bold text indicates significant results (P-value ≤ 0.01).