Fig. 2: Proteins genetically linked to various COVID-19 outcomes.
From: ELF5 is a potential respiratory epithelial cell-specific risk gene for severe COVID-19
Odds ratios (rectangles) and 95% CIs (lines) for the genetically predicted effect of protein levels on three different outcome definitions and control populations for COVID-19 (left), including protein targets with strong evidence for statistical colocalisation for at least one definition (right). Proteins are ordered by absolute effect size for severe COVID-19. The column in the middle reports the p values for Wald ratio estimates from a single variant Mendelian randomisation analysis. Stacked bar charts represent the posterior probability that protein levels and COVID-19 outcomes share a genetic signal in a 500 kb flanking region of the protein-encoding gene (black) or rather represent two distinct signals (grey). For each protein, the proteomics platform and the protein-encoding gene (in brackets) are listed. ELF5 ETS-related transcription factor Elf5, OAS1 2′–5′-oligoadenylate synthase 1, HSP40 DnaJ homologue subfamily B member 1, RAB2A Ras-related protein Rab2A, NUDT5 ADP-sugar pyrophosphatase, SFTPD Pulmonary surfactant-associated protein D, G-CSF Granulocyte colony-stimulating factor, BGAT Histo-blood group ABO system transferase. The data underlying this figure is given in Supplementary Data 5. Sample sizes for COVID-19 outcomes can be found in Supplemental Table 1; 10,708 and 485 participants were included for SomaScan and Olink analysis, respectively.
