Fig. 7: A single immunization with IBV pentavalent mRNA-LNP vaccine prevents virus replication. | Nature Communications

Fig. 7: A single immunization with IBV pentavalent mRNA-LNP vaccine prevents virus replication.

From: Development of a pentavalent broadly protective nucleoside-modified mRNA vaccine against influenza B viruses

Fig. 7

Mice were I.D. vaccinated once with 5 μg of monovalent mRNA-LNPs or with 5 μg/antigen or 1 μg/antigen of the pentavalent mRNA-LNP formulation. Control animals received 5 μg of luciferase mRNA-LNP. Virus titers in the lung homogenate of mRNA-LNP-vaccinated mice at 3 and 6 dpi following I.N. challenge with 1mLD50 of B/New York City/PV01181/2018 (V) (n = 3 mice/group) (a). Virus titers in the lung homogenate of mRNA-LNP-vaccinated mice at 3 and 6 dpi following I.N. challenge with 1mLD50 of B/New York City/PV00094/2017 (Y) (n = 3 mice/group) (b). Each symbol represents one animal and the average is presented as the group mean. The dotted lines indicate the limit of detection. Source data are provided as a source data file.

Back to article page