Fig. 6: Overexpression of ChREBPβ leads to β-cell death, glucose intolerance and diabetes.
From: Maladaptive positive feedback production of ChREBPβ underlies glucotoxic β-cell failure
a LSL-ChREBPβ mice were bred with MIP-Cre-ERT mice to generate inducible β-cell-specific overexpressing ChREBPβ mice, termed iβOEβ (created with BioRender.com; see also Supplementary Figs 16 and 17). Presented are measurements from male mice (see also Supplementary Fig. 18 for female mice). b, c Glucose tolerance test and area under the curve (AUC) one week after vehicle oil or tamoxifen treatment. d Weekly measures of whole body weight. e Plasma Insulin levels after one week. f Non-fasting blood glucose levels for the indicated times and treatment groups. g β-cell mass (BCM) one week after vehicle oil or tamoxifen treatment. h, i Glucose tolerance test and area under the curve (AUC) one month after vehicle oil or tamoxifen treatment. j β-cell mass (BCM) one month after vehicle oil or tamoxifen treatment. Data are means ± SEM, N = 4–6; *p < 0.05; **P < 0.001; ****P < 0.0001 using two-way ANOVA. k, l Percent Ki67-postive and insulin-positive cells in pancreata from male homozygous iβOEβ mice 1 week after oil or tamoxifen injection. m, n Percent TUNEL-positive and insulin-positive cells in pancreata from male homozygous iβOEβ mice 1 week after oil or tamoxifen treatment. Data are means ± SEM from five mice/group. *p < 0.05 using two-way ANOVA.
